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(E)-Nerolidol 35.5% + fokienol 26.4% + cadinane-class alcohol co-DOM produces sustained heavy base-note aroma traditionally associated with emotional grounding and nervous-system settling, consistent with the patchouli/vetiver/guaiacwood sesquiterpene-alcohol-DOM cluster.

Ref: class-extrapolation from patchouli (EO072), vetiver, guaiacwood (sesquiterpene-alcohol-base-note cluster); Tisserand & Young 2014

(E)-Nerolidol (35.5%) displays anticarcinogenic activity per B216 Ch.14 constituent profiling; α-cadinol within the cadinane-class co-DOM (~55%) demonstrated activity against the HT-29 human colon cancer cell line in vitro — multi-mechanism signal across two constituent families.

Ref: B216 Chapter 14 — Nerolidol profile; He, K. et al (1997a)

Sesquiterpene-alcohol-class constituents (nerolidol 35.5%, cadinane α-cadinol + T-cadinol co-DOM ~55%) are associated with anti-inflammatory mechanisms by class; eudesmane eudesmol (~10%) further supports a multi-constituent anti-inflammatory class signal.

Ref: class-extrapolation from guaiacwood (Tisserand & Young 2014 Ch.14 sesquiterpene-alcohol-class)

Sesquiterpene alcohols — nerolidol, α-cadinol, T-cadinol, and T-muurolol — are well-characterized for broad-spectrum antimicrobial activity; the combined ~55% cadinane-class co-DOM reinforces this multi-constituent signal.

Ref: class-extrapolation from patchouli (EO072) cadinane-alcohol-class; Tisserand & Young 2014 Ch.14

(E)-Nerolidol carries an extremely-low skin-sensitization-potential rating per B216 Ch.14 constituent safety profiling; the Fokienia hodginsii EO profile shows no skin sensitizers among its dominant constituents and no known hazards (B216 'None known × 2' data gap).

Ref: B216 Chapter 14 — Nerolidol profile; Tisserand & Young 2014