Celery leaf (Apium graveolens L.) — họ Apiaceae (Umbelliferae) — culinary-Apiaceae-leafy-aerial commercially steam-distilled from leaves+stems mostly in France + India + Netherlands. Constituent β-Myrcene 33.6% MAJOR-DOM acyclic-monoterpene + (+)-Limonene 26.3% co-MAJOR + (Z)-β-Ocimene 14.1% + 3-Butyl phthalide 6.2% + β-Selinene 3.7% + 3,4-Dehydroisobutylidene phthalide 3.2% + n-Pentylcyclohexadiene 1.0% (Lawrence 1989 p.157 per B216 p.517).
Hazards B216 EXPLICIT verbatim: "Skin sensitization if oxidized." Cautions B216 EXPLICIT verbatim: "Old or oxidized oils should be avoided."
Framework 5% adult dermal (B216 no specific cap).
Adverse skin reactions B216 EXPLICIT: "No information found. Autoxidation products of (+)-limonene can cause skin sensitization (see (+)-Limonene profile, Chapter 14)."
Reproductive toxicity B216 EXPLICIT verbatim: "Oral β-myrcene was reproductively toxic in pregnant rats at 500 mg/kg, but not at 250 mg/kg (Delgado et al 1993a, 1993b; Paumgartten et al 1998). This does not suggest any dose limitation for celery leaf oil." — class-rail conservative-evidence (low-dose β-myrcene safe at typical aromatherapy dilution).
Acute toxicity B216 EXPLICIT: "No information found. β-Myrcene and (+)-limonene are non-toxic (see Constituent profiles, Chapter 14)."
Carcinogenic potential B216 EXPLICIT verbatim: "No information found for celery leaf oil. β-Myrcene is not genotoxic and demonstrates antigenotoxic activity; it is a male mouse-specific hepatocarcinogen (see β-Myrcene profile, Chapter 14). 3-Butyl phthalide and (+)-limonene display anticarcinogenic activity (see Constituent profiles, Chapter 14)."