Thận trọngNốt hương đầu — giữaSweet-balsamic-spicy

⚠️Tinh dầu này cần thận trọng khi sử dụng. Đọc kỹ hướng dẫn an toàn.

Tổng Quan

Danh pháp khoa học: Sassafras albidum (Nutt.) Nees
Họ thực vật: Lauraceae
Bộ phận dùng: Wood and/or roots
Phương pháp chiết xuất: Chưng cất hơi nước
Phân loại nốt hương: Nốt Top/Middle

Các quốc gia sản xuất chính

USABrazilChina

Tình trạng tại Việt Nam

Xem chi tiết

Phân loại nốt

Đầu — Giữa

Độ bền trên da

2–4 giờ

Họ hương

Sweet-balsamic-spicy

Mô tả hương

ngọt, nhựa thơm, cay, root-beer-đặc-trưng, gợi hồi, long não nhẹ, thoảng cam thảo, thơm đậm, ấm, nhựa, thoảng nhục đậu khấu, sassafras-mang-tính-biểu-tượng

Cường độ hương

5/5

Da khô

1/5

Da dầu/mụn

1/5

Da lão hóa

1/5

Da thường

1/5

Da nhạy cảm

1/5

Da hỗn hợp

1/5

Nhập khẩu

Tên gọi tại Việt Nam

Tinh dầu sassafras — CHỐNG CHỈ ĐỊNH HOÀN TOÀN (carcinogenic, safrole 85.5–97%)

An Toàn

Giới hạn bôi da

Theo hồ sơ an toàn (người lớn)

Bảo quản

Bảo quản nơi tối, mát

Xem hồ sơ an toàn chi tiết

Pha Chế & Hòa Hợp

Historical analgesic / rubefacient

Safrole-dominant oil was historically applied as a mild counterirritant and flavoring; all such uses are prohibited due to safrole metabolic activation via 1'-hydroxysafrole and 2',3'-epoxysafrole intermediates forming hepatic DNA adducts.

Ref: Tisserand & Young 2014 (B216 p.813-815); US FDA 1960

Rodent hepatocarcinogen — safrole metabolic activation

Safrole (61.7–97%) undergoes CYP2E1/CYP1A2 activation to 1'-hydroxysafrole and 2',3'-epoxysafrole, forming DNA adducts with liver macromolecules producing hepatocellular carcinoma in rats; human relevance supported by structural analogy.

Ref: B216 Chapter 14 — Safrole profile; Abbott et al 1961; Miller 1979

Additive carcinogen — methyleugenol class (C. rigidissimum)

In Cinnamomum rigidissimum-sourced oil, methyleugenol (28.6%) adds a second metabolically-activated carcinogen class; both constituents share epoxide-intermediate DNA-adduct mechanisms producing cumulative hepatic carcinogenicity.

Ref: Zhu et al 1993; B216 Chapter 14 — Methyleugenol profile; IFRA 2009; European Commission 2002

Acute oral toxicity (low-moderate)

Acute oral LD50 1.9 g/kg rat (S. albidum) and 1.58 g/kg (O. pretiosa); case reports document survival after 4–60 mL ingestion in children with significant CNS and GI toxicity; chronic carcinogenic risk far exceeds the acute hazard threshold.

Ref: Opdyke & Letizia 1982 (RIFM p.825-826); Opdyke 1978 (RIFM p.831); Craig 1953; Grande & Dannewitz 1987

AI-summary

No therapeutic RCTs exist for sassafras essential oil. The oil is classified CONTRAINDICATED ALL ROUTES by Tisserand & Young 2014 due to safrole (61.7–97%), a rodent hepatocarcinogen prohibited as a food additive by US FDA since 1960. Abbott et al (1961) demonstrated hepatocellular carcinoma in rats on 390–1170 ppm dietary safrole/sassafras oil. Miller (1979) reported 95% lethality at 10,000 ppm over 19 days. RIFM patch-test data (Opdyke 1982, Rudzki 1976) show no immediate skin sensitization at low concentrations — but this does not mitigate chronic carcinogenic risk. All historic therapeutic applications (rubefacient, flavoring, tooth-pain analgesic) are superseded by the carcinogenicity classification. CITES listing for Ocotea odorifera is proposed pending per UNEP-WCMC.

Narrative

Tâm trạng: Đặt vững, Kích thích

mysterywildnessancestralgroundingwarmthprimal

Chakra

Luân xa Gốc

Ngũ hành

Mộc

Phương pháp	Liều lượng	Ghi chú
Diffusion — professional research context only	1–2 drops in well-ventilated space; 5–10 min max; professional use only	For professional research or organoleptic-reference only. NOT for personal aromatherapy or home diffusers. Chronic safrole vapour risk extrapolated from dietary carcinogenicity studies (Abbott 1961).
Hazard reference only — not for therapeutic use	N/A — oil must not be applied or ingested under any circumstances	ALL routes contraindicated per Tisserand & Young 2014. US FDA prohibited safrole and sassafras as food additives in 1960. Do NOT apply to skin, ingest, or blend for personal therapeutic use.

Dầu nền phù hợp

None — topical use contraindicatedTopical application of sassafras essential oil is contraindicated per Tisserand & Young 2014 due to safrole (61.7–97%) carcinogenicity; no carrier pairing is appropriate for any dermal application.

Kết hợp tốt với

GỗNhựa câyĐất ẩmLong não

Blend kinh điển

Cedarwood (Virginian)— Cedarwood's dry woody architecture grounds safrole's sweet phenolic warmth, building a dense forest-floor accord with shared heartwood character.

Patchouli— Patchouli's deep earthy sesquiterpenes amplify sassafras's root-bark warmth into a layered ancestral accord steeped in earth and history.

Clove Bud— Clove's eugenol warmth harmonizes with safrole's anisic-phenolic sweetness through shared phenylpropanoid chemistry and dark spiced-wood character.

Frankincense— Frankincense's resinous camphoraceous lift balances sassafras's heavy sweet-phenolic depth, tempering wildness with sacred incense smoke.

[Tisserand & Young 2014] Essential Oil Safety: A Guide for Health Care Professionals, 2nd ed., Churchill Livingstone Elsevier (B216, p.813-815). Primary clinical safety source. CONTRA-ALL classification authoritative.

[Phongpaichit, S., et al] chemistry source for Cinnamomum porrectum (Chinese sassafras) safrole 85.5-97.0% cited in B216 p.813.

[Zhu, L., et al] chemistry source for Cinnamomum rigidissimum (Chinese sassafras) safrole 61.7% + methyleugenol 28.6% cited in B216 p.813.

[Formacek, V. & Kubeczka, K.-H.] Essential Oils Analysis by Capillary Gas Chromatography and Carbon-13 NMR Spectroscopy — chemistry source for Ocotea odorifera cited in B216 p.813.

[Zwaving, J. H. & Bos, R.] chemistry source for Sassafras albidum roots safrole 82.8-88.8% cited in B216 p.813.

[Opdyke, D. L. J. & Letizia, C.] RIFM monograph p.825-826 — Sassafras albidum clinical-clean rail (4%/25 volunteers, non-phototoxic, LD50 oral 1.9 g/kg, dermal >5 g/kg).

[Opdyke, D. L. J.] RIFM monograph p.831 — Brazilian sassafras (Ocotea pretiosa) 20%/25 volunteers clinical-clean + LD50 oral 1.58 g/kg + dermal >5 g/kg.

[Rudzki, E., et al] 200 dermatitis patients none sensitive to 2% sassafras oil patch test.

[Craig, J. O.] sassafras oil ingestion case reports (5 children survived 4-60 mL each + adult 1888 US Dispensatory case veracity assessment).

[Grande, G. A. & Dannewitz, S. R.] 47-year-old 5 mL ingestion survival + symptoms case report.

[Abbott, D. D., et al] 22-month rat dietary safrole / sassafras oil 390/1170 ppm carcinogenicity study.

[Miller, J. A.] safrole carcinogenic + 95% lethal rats 10,000 ppm 19-day dosing reference.

[B216 Chapter 14 — Safrole profile] class-mechanism source for carcinogenicity rail; metabolic activation 2',3'-epoxy + 1'-hydroxy + 1'-sulfate intermediate DNA adducts liver macromolecules.

[B216 Chapter 14 — Methyleugenol profile] class-mechanism source for additive carcinogen exposure.

[IFRA 2009] methyleugenol 0.0004% leave-on cosmetic cap.

[European Commission 2002] SCCNFP methyleugenol 0.0002% finished-product cap.

[US FDA 1960] sassafras oil + safrole prohibited as food additive.

[UNEP-WCMC] Ocotea odorifera CITES proposed Appendix listing pending.

[APG-IV] Lauraceae family + Laurales order taxonomy.

Kỹ Thuật

Tổng định danh

~90–98%

Tinh dầu sassafras — CHỐNG CHỈ ĐỊNH HOÀN TOÀN

Chân dung Hương

Mang tinh chất này vào sáng tạo của bạn

Tổng Quan

An Toàn

Pha Chế & Hòa Hợp

Kỹ Thuật

Tóm Tắt Khoa Học

Dữ Liệu Kỹ Thuật Y Khoa

Khám phá tiếp

Thông Số Định Lượng

Luận Giải Văn Cảnh